Tree-Hugging Dirt Worship

April 18, 2013

Sasha Shulgin on Animal Research

Filed under: science, Soapbox — Tags: , , , , , , — paragardener @ 5:18 pm

From “PiKHAL, a chemical love story:”

This (MME) is one of the very few compounds with which I actually risked (and took) the lives of experimental animals. I was still impressed by the scientific myth that pharmacological research wasn’t really acceptable without animal support data. And I had access to an experimental mouse colony at the University. I injected one mouse with a dose of 300 mg/Kg., i.p. That sounds pretty scientific. But what it really means is that I picked up a mouse by the scruff of the back with my left hand, then turned my hand over so that the mouse was belly-up. I put the ring finger over a hind leg to keep things relatively immobile. Usually at this point there is a little urine evident where there had been none before. And I took a syringe equipped with a very fine needle and containing about 8 milligrams of MME in a fraction of a mL of a water solution and pushed that needle into the mouse at about where the navel would be if one could see the mouse’s navel, and then I pulled the needle back just a little so that there should be nothing at the business end but the loose folds of the peritoneum. Then I pushed the syringe plunger home, effectively squirting the water solution into the area that surrounds the intestines. I dropped the mouse back into his cage, and watched. In this case, the mouse went into a twitching series of convulsions (known as clonic in the trade) and in five minutes he was dead.

Fired with the lust for killing, I grabbed another mouse, and nailed him with 175 mg/Kg. Dead in 6 minutes. Another one at 107 mg/Kg. Dead in 5 minutes. Another at 75 mg/Kg. Well, he looked pretty sick there for a while, and had some shakes, and then he seemed to be pretty much OK. One final orgy of murder. I injected 5 mice at 100 mg/Kg i.p., and watched four of them die within 20 minutes. I took in my hands the sole survivor, and I went outside the laboratory and let him loose on the hillside. He scampered away and I never saw him again.

And what did I learn, at the cost of seven precious lives which I can never replace? Not a damned thing. Maybe there is an LD-50 [the dose lethal to 50% of the animals] somewhere around 60 or 80 mg/Kg. This is for mice, not for men. I was intending to take an initial trial dose of 300 micrograms of this completely untested compound, and it would have made no difference to me if the LD-50 had been 600 mg/Kg or 6 mg/Kg.  I still took my trial dose, and had absolutely no effects, and I never killed another mouse again. No, that is simply out-and-out dishonest. I had an invasion of field mice last winter coming up through a hole in the floor behind the garbage holder under the kitchen sink, and I blocked the hole, but I also set some mouse traps. And I caught a couple. But never again for the simple and stupid reasons of being able to say that “This compound has an LD-50 in the mouse of 70 mg/Kg.” Who cares? Why kill?

If you believe in something you are creating, there should be no problem in trying it out for yourself first. Shulgin’s usual protocol for trying new drugs is to start with perhaps 1/500 of the expected active dose, and then taste again next week with double or 1.5 times as much. If there are signs of activity, whether amusing or toxic, the next dose will only be a small increment more.

Shulgin’s intent is purely to make new compounds for exploring the mind, which generally fall near the psychedelic category. Not very much is known about the possible health effects of most of the (over 200) new compounds he’s synthesized.

Yet, I feel a lot better with the idea of taking an exploratory compound cooked up by an eccentric and earnest scientist, than buying shampoo at the store that was rubbed into bunny eyes as a Cover Your Ass move, but which was actually created by people whose only interest lay in making money. Monsanto represents an ultimate in ugly innovation, removing GMO items from their own cafeterias because their employees don’t want to eat what they are growing.

If corporate scientists don’t want to test their new creations on themselves, I understand why. They are just working on orders from above, acting as competent technicians. I am all in favor of testing on the people in charge: the Board of Directors, the CEO and management team, and the major shareholders.

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March 23, 2013

Regulate Breathing

My life’s ambition, my abstract love and enthusiasm for life, is to study psychoactive substances, or mind-altering drugs as you might call them. This is a bit frustrating, like being a born musician in Taliban country.

The Lords of the US gather in Bohemian Grove every year, surrounded by acres of empty forest, to privately party and drink and get down with Sasha Shulgin, inventor of most every designer psychedelic or party drug ever. Then they fly back to Washington, D.C. to publicly give speeches about the evils of drugs and vote for increased penalties and ban new substances (usually Shulgin’s inventions after about an eight-year lag time.) To coordinate the message that “drugs are bad, m’kay,” the Office of National Drug Control Policy writes pieces of television scripts and pays the networks to include them in their programming. Most people accept the message: to be “into drugs” isn’t an innocent thing like being “into music” or “into cars,” it’s tantamount to being a thieving junkie.

Sometimes I hear people say, “oh, drugs are an inferior way of exploring altered states. You can get to the same places with breathing exercises and meditation, whilst maintaining the virgin purity of your blood.” Okay, that’s not exactly what they say, but you get the idea…

I used to mentally respond to them, “yeah, right. I’m sure that is almost true if you withdraw from the world and spend years training in a Himalayan monastery, but in the real world meditation only gets me a few minutes of relaxation. And even if meditation brought me to the Ultimate Enlightenment, I kind of liked seeing the pretty colors, too, and I’m sure that that was a specific effect of the drugs.”

Now, new information has come to light, and I do believe that I may have been missing something about the breathing. A certain Pau reported a pretty heavy trip from doing breathing exercises right before bed:

Some years ago , just a few weeks after I learned about mediation and pranayama breathing exercises, I was practicing pranayama for a few minutes before I went to bed. At the same time I was attempting to quiet my mind (which I believe is easier to do while doing pranayama).

I broke through, with infinite power…I lost all sense of body, and my consciousness expanded in a fraction of a second to fill and become the entire universe … I “felt” there was nothing I could not know or see about the past present and future of everything. There had not been any psychedelics in my system for a year. Yeah, the speck of “I” that was rapidly disappearing during this event got freaked out and decided with great effort to switch the experience off before the “I” was gone for good. But the same thing happened the following night. (both times, before the blastoff, there was a period of maybe half a minute where everything around me, including empty space, seemed like it was made of sparkling blue dots).

This, in the context of a thread about boosting endogenous DMT, the powerful and illegal psychedelic that is a natural component of your body, everyone else, hundreds of plant species, and most higher animals. Is this a case of manufacturing illicit drugs? Pranayama seems to be a widespread practice with many variations, go ahead and look it up and you will find dozens of teachers providing you the training online. It seems foremost like an exercise to make breathing more conscious, although it goes beyond the simple Zen-derived techniques I’ve studied in the past.

Another way to breathe your way into an altered state is to suck a mixture of carbon dioxide and oxygen. During the 1960’s, when scientists could work with psychedelics and not be charged with witchcraft, there was a great interest in psychedelics as part of psychotherapy. There was some risk of giving a dose of LSD to a client and then watching helplessly as they experienced an eight-hour trainwreck of anxiety and confusion, so there was a desire to find a way of inducing a briefer altered state to test the waters. Such a way already existed, and it was called carbogen: typically, a mixture of 70% oxygen and 30% carbon dioxide.

People who were administered carbogen in a clinical setting, as a trial of their ability to weather altered states, typically freaked out. But not always:

“After the second breath came an onrush of color, first a predominant sheet of beautiful rosy-red, following which came successive sheets of brilliant color and design, some geometric, some fanciful and graceful …. Then the colors separated; my soul drawing apart from the physical being, was drawn upward seemingly to leave the earth and to go upward where it reached a greater Spirit with Whom there was a communion, producing a remarkable, new relaxation and deep security.”

Wow! Pretty colors and all!

Society’s controllers have been obsessed with preventing the common folk from having religious experiences since the Christian church merged with the Roman Empire almost 2,000 years ago (a few visionaries were sainted, more were burned at the stake). So, the fact that one can manipulate one’s own lungs and atmospheric gasses to induce such experiences presents a challenge to authority.

Perhaps the situation can be brought back under control. Progressive Insurance offers drivers a device called “Snapshot,” which monitors basics like acceleration and stopping time, and gives drivers a discount for safe practices. All Americans who have two pennies to rub together will soon be looking for discounts for their newly mandatory “Affordable Care” very soon. Why not strap a Snapshot consisting of a pedometer and a polygraph to every American, and offer them discounts for “safe biometrics?”

One strap around the abdomen, and one around the chest, and any hanky-pranayama that might occur will signal your insurance company to jack up your premiums. If you aren’t abusing your ability to breathe, you have no reason to object to such a proposition.

Breathing should be subject to reasonable regulation, just like food, water and medicine. Breathing is too important a matter to leave to individuals with their pesky notion of “rights” and their ignorance. After all, people like you and me were never properly trained or licensed to breathe. Breathing disorders are a leading cause of death.

Not funny? Sorry, but…

I’m suffocating over here!!!

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